H. Marotte, L. Gossec, V. Abitbol, E. Senbel, G. Bonnaud, X. Roblin, Y. Bouhnik, S. Nancey, N. Mathieu, J. Filippi, L. Vuitton, S. Nahon, A. Dellal, A. Denis, C. Habauzit, S. Benkhalifa, G. Bouguen. EULAR 2024. 12-15 June 2024, Vienna, Austria.
Background: Switching from a reference product (RP) to a biosimilar (BS) aims to generate savings. Patient adherence after a switch is linked to overall experience that can be impacted by patient or treatment characteristics.
Objectives: This study aimed to analyse patient-experience and satisfaction after the switch from an adalimumab (ADA) RP or BS to CT-P17[1] (ADA BS high concentration (HC), citrate-free).
Methods: YU-MATTER (NCT05427942), a multicentric prospective observational study included patients with chronic inflammatory rheumatic disease (CIR) or inflammatory bowel disease (IBD) treated with ADA: either the RP (HC: 100mg/ml) or a BS with low concentration (LC: 50mg/ml). Patients were switched to CT-P17 and followed-up for 3 months (M). Clinical characteristics were collected at M0, including patient-experience via 5 self-questionnaires developed in collaboration with patient associations to explore satisfaction regarding the injection (Likert 7), discomfort (pain [NRS 0-10], redness [Likert 4], itching [NRS 0-10], and haematoma [Likert 3]). Satisfaction and overall injection tolerance (pain < 4 AND absence of redness AND itching < 4 AND absence of haematoma) were assessed between M0 (just before switch) and M3 (3 months after switch). Factors associated with satisfaction improvement (Likert) were explored through multivariable logistic regression.
Results: Of the 232 patients analysed, the rheumatology population counted 65 patients with CIR (RA=17, AS=35, nr-axSpA=7, PsA=6,). mean age was 54±9 years; median disease duration was 9 years ([Q1; Q3]: [5; 18]) and 49.2% were men. Over the analysed population, 119 (51.2 %) patients were switched from a BS (45 with citrate) and 113 (48.7%) from the RP. At 3 months, 175 patients (75.4%) were satisfied with the injection and 145 (62.5%) had a stable or improved satisfaction versus the previous ADA. Among patients receiving a BS, the presence of citrate was significantly associated with an improvement of satisfaction after switching to CT-P17 (58.3% vs. 30.0%, p=0.006). Overall injection tolerance significantly improved after switching from 28.9 % at M0 to 57.7 % at M3 (p<0.0001). A significant decrease of pain related injection was observed after the first injection of CT-P17 (median -2 [-4;-1]) for patients switched from a BS and remained stable for patients switched from the RP (median 0 [-1;1]). In multivariable analysis, the switch from a LC ADA was an independent factor of satisfaction improvement (vs from the RP, odds ratio=3.03; p=0.003; Table 1).
Conclusion: The global experience of switching to CT-P17 was positive with an overall improvement in injection tolerance. Injection volume was an independent factor associated with a successful experience.
(Poster) H. Marotte, L. Gossec, V. Abitbol, E. Senbel, G. Bonnaud, X. Roblin, Y. Bouhnik, S. Nancey, N. Mathieu, J. Filippi, L. Vuitton, S. Nahon, A. Dellal, A. Denis, C. Habauzit, S. Benkhalifa, G. Bouguen. Patient satisfaction and experience after a switch to an adalimumab biosimilar with high concentration and citrate-free: results from a multicentric prospective real-life study. AB1493. EULAR 2024. 12-15 June 2024, Vienna, Austria.
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