Ouedraogo, Elise, Lucie Allard, Hélène Bihan, Jeanne Goupil de Bouillé, Bénédicte Giroux-Leprieur, Angela Sutton, Camille Baudry, et al. “The Association of Metabolic Syndrome and COVID-19 Deterioration. Research Article in Nutrition, Metabolism and Cardiovascular Diseases (Octobre 2021)
Background and aims: To evaluate the prevalence and prognostic value of metabolic syndrome (MetS) in patients admitted for coronavirus disease 2019 (COVID-19).
Methods and results: In this monocentric cohort retrospective study, we consecutively included all adult patients admitted to COVID-19 units between April 9 and May 29, 2020 and between February 1 and March 26, 2021. MetS was defined when at least three of the following components were met: android obesity, high HbA1c, hypertension, hypertriglyceridemia, and low HDL cholesterol. COVID-19 deterioration was defined as the need for nasal oxygen flow 6L/min within 28 days after admission. We included 155 patients (55.5% men, mean age 61.7 years old, mean body mass index 29.8 kg/m2). Fifty-six patients (36.1%) had COVID-19 deterioration. MetS was present in 126 patients (81.3%) and was associated with COVID-19 deterioration (no-MetS vs MetS: 13.7% and 41.2%, respectively, p < 0.01). Logistic regression taking into account MetS, age, gender, ethnicity, period of inclusion, and Charlson Index showed that COVID-19 deterioration was 5.3 times more likely in MetS patients (95% confidence interval 1.3e20.2) than no-MetS patients.
Conclusions: Over 81.3% of patients hospitalized in COVID-19 units had MetS. This syndrome appears to be an independent risk factor of COVID-19 deterioration.
(Publication) Ouedraogo, Elise, Lucie Allard, Hélène Bihan, Jeanne Goupil de Bouillé, Bénédicte Giroux-Leprieur, Angela Sutton, Camille Baudry, et al. 2021. “The Association of Metabolic Syndrome and COVID-19 Deterioration.” Nutrition, Metabolism and Cardiovascular Diseases 31 (11): 3236–42. https://doi.org/10.1016/j.numecd.2021.08.036.